What is Acidic Domain in Molecular Biology? PDF Book

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Acidic Domain Definition

  • A transcription-activating domain rich in acidic amino acids..

    Molecular Biology by Robert F. Weaver



Acidic Domain Explanation

Acidic domain, as the name implies, is an amino acid rich, transcription activating domain in cells. For example, in EBV (Epstein-Barr virus) infected cells, the domain that is required for activation of transcription is present at the C terminus and is constituted by two very different amino acid regions, and the one that is more acidic (the second putative α-helix) is an activating domain. While the other proline rich region is not self sufficient for such activation.

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