What is Apurinic Site (AP Site) in Molecular Biology? PDF Book

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Apurinic Site (AP Site) Definition

  • A deoxyribose in a DNA strand that has lost its purine base..

    Molecular Biology by Robert F. Weaver

Apurinic Site (AP Site) Explanation

Apurinic Site (AP Site) is the location on a DNA strand (or in RNA sometimes), that does not carry a purine base. In other words the purine bases from the strand are lost either spontaneously or due to some damage. It is estimated that on a daily basis, about 10,000 apurinic sites can be generated in a cell under physiological conditions.

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